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Published on: March 1, 2024
[Study on preparation of glycyrrhiza total flavones effective components sustained-release pellets and its
Li-Hua Chen1, Yi Feng, De-Sheng Xu
1Shanghai University of TCM, Shanghai 201203, China. chlly98@163.com
Objective:
To prepare the glycyrrhiza total flavones effective components pellets by extrusion-spheronization, and to optimize the formulation of glycyrrhiza total flavones effective components sustained release pellets coated with mixed Eudragit RS 100.
Methods:
The sustained-release pellets of glycyrrhiza total flavones were prepared by Glatt fluid bed technique. The factors influencing the drug release behaviors and their properties were evaluated.
Results:
The optimal drug sustained-release was shown at the loading weight of copolymers of 6% and the plasticizer concentration of 10%. And the curves of cumulative drug release were fit for Peppas and Higuchi equation.
Conclusion:
The pellets show obviously sustained-release effect.
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