Related Experiment Video
Updated: Jul 3, 2026
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[A new flavonoid from heartwood of Caesalpinia sappan]
Shi-Hui Shu1, Jing-Lan Han, Guan-Hua Du
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China.
Objective:
To seek for new active components from Caesalpinia sappan.
Method:
The chemical constituents were isolated and identified by means of chromatographic and spectroscopic technologies methods.
Result:
Nine compounds were isolated, and their structures were identified as 3, 8-dihydroxy4, 10-dimethoxy-7-oxo-[2] benzopyrano[4,3-b] benzopyran (1), 3-deoxysappanchalcone (2), sappanchalcone (3), 3-deoxysappanone B (4), rhamnetin (5), protosappanin C (6), 3, 7-dihydroxy-chroman-4-one (7), dimethyl adipate (8), daucosterin (9).
Conclusion:
Compound 1 was a new compound, and compounds 7, 8 were isolated from this plant for the first time.
Related Concept Videos
01:25Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
01:20Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
03:24Seedless Vascular Plants