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Updated: Jul 3, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Systemic lupus erythematosus: future therapeutic avenues]
Z Amoura1, J Haroche, J-C Piette
1Service de médecine interne 2, centre national de référence Lupus et syndrome des anticorps antiphospholipides, université Pierre-et-Marie-Curie, Paris-6, CHU Pitié-Salpétrière, 75013 Paris cedex 13, France. zahir.amoura@psl.aphp.fr
La Revue De Medecine Interne
|July 16, 2008
Summary
New biotherapies targeting the immune response are emerging for systemic autoimmune diseases like lupus erythematosus. These innovative treatments focus on B lymphocytes, T lymphocytes, and cytokines to improve patient outcomes.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Context:
- Systemic autoimmune diseases, particularly systemic lupus erythematosus (SLE), have seen advancements in treatment strategies.
- Recent decades have witnessed a deeper understanding of the immune response, paving the way for novel therapeutic targets.
Purpose:
- To review and outline emerging biotherapies for systemic autoimmune diseases, with a focus on SLE.
- To categorize these new treatments based on their mechanisms of action within the immune response.
Summary:
- Biotherapies under development for SLE target key components of the immune system.
- These include inhibitors of B lymphocytes (e.g., anti-CD20, anti-CD22, BlyS antagonists), costimulation inhibitors between antigen-presenting cells and T lymphocytes (e.g., anti-CD40 ligand, CTLA-4-Ig), and cytokine antagonists (e.g., targeting IL-10, IFN-alpha, IL-6, TNF).
Impact:
- These novel therapies represent a paradigm shift in managing SLE, moving towards targeted immunomodulation.
- Successful development and application of these biotherapies could significantly improve the prognosis and quality of life for SLE patients.
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