Related Experiment Video
Updated: Jul 3, 2026

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Subjective alcohol effects and drinking behavior: the relative influence of early response and acquired tolerance
Meghan E Morean1, William R Corbin
1Yale University Department of Psychology, 2 Hillhouse Avenue, New Haven, CT 06511, United States. Meghan.Morean@Yale.edu
Objectives:
(1) To establish the reliability and validity of a modified version of the Self-Rating of Alcohol (SRE) form. (2) To differentiate early subjective alcohol response (SR) from acquired tolerance in the prediction of drinking outcomes.
Method:
353 undergraduates completed an online survey. SR was assessed using the SRE form and a modified SRE including items assessing global stimulant and sedative effects. The Daily Drinking Questionnaire-Revised (DDQ-R), and the Rutgers Alcohol Problems Index (RAPI) assessed alcohol use and problems, respectively.
Results:
The revised version of the SRE showed good internal consistency and incremental validity. Early SR assessed by the modified SRE was consistently associated with use and problems. Acquired tolerance was significantly related to use and problems above and beyond early SR.
Conclusions:
The modified SRE incorporating stimulant and sedative responses demonstrated good psychometric properties and the potential to capture unique variability in drinking outcomes. Differentiating early SR from tolerance showed that each contributes uniquely to drinking behavior and problems. Thus, future studies would benefit from examining the unique contribution of each aspect of SR.
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Acidity and Basicity of Alcohols and Phenols
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Physical Properties of Alcohols and Phenols
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Aldehydes and Ketones with Alcohols: Hemiacetal Formation
Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms:

