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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
[Helminths and inflammatory bowel diseases]
C Laclotte1, A Oussalah, P Rey
1Inserm, U724, France.
Gastroenterologie Clinique Et Biologique
|July 16, 2008
Summary
Exposure to helminths, like Trichuris suis, may benefit inflammatory bowel diseases (IBD) by modulating immune responses. Studies suggest helminths reduce inflammation and are well-tolerated, but long-term safety requires further investigation.
Area of Science:
- Immunology
- Gastroenterology
- Epidemiology
Context:
- Inflammatory bowel diseases (IBD), such as Crohn's disease, are prevalent in industrialized nations and linked to altered immune responses.
- The "hygiene hypothesis" suggests reduced exposure to infectious agents, including helminths (worms), impacts childhood immune development.
- Helminths are inversely correlated with IBD prevalence globally and possess immunomodulatory properties.
Purpose:
- To explore the immunological basis for helminth therapy in inflammatory bowel diseases.
- To evaluate the potential of helminth exposure, specifically Trichuris suis, as a treatment for Crohn's disease.
Summary:
- The etiologic model of IBD involves genetic predisposition and environmental triggers leading to aberrant immune responses.
- Helminths naturally colonizing humans dampen immune hyper-responsiveness, shifting T-helper (Th1) pathways towards Th2 and inducing regulatory T cells.
- This immunomodulation suggests helminths can reduce inflammation and maintain mucosal homeostasis, offering a potential therapeutic strategy for IBD.
Impact:
- Helminth exposure demonstrates potential as a safe and well-tolerated treatment for inflammatory bowel diseases.
- Further research is needed to establish the long-term safety and efficacy of helminth therapy in IBD patients.
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