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Use of LHRH-agonists as adjuvant therapy for breast cancer
1University of London, Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary, Charterhouse Square, London, EC1M 6BQ, UK. jack.cuzick@cancer.org.uk
Abstract:
Individual data was collected for 11,906 women in 16 randomised trials evaluating a luteinising-hormone-releasing hormone (LHRH) agonist either alone, as an addition to tamoxifen or chemotherapy or in place of chemotherapy. When used alone these agents led to a large (28%) relative decrease in recurrence, which was not significant (p = 0.08) due to the small number of patients randomised. Addition of LHRH-agonist to tamoxifen, chemotherapy or both, reduced recurrence by 13% (p = 0.02), and when used alone these agents showed similar efficacy to chemotherapy. The largest effect after chemotherapy was seen in women aged
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