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The centrosome is a polyfunctional multiprotein cell complex.

I B Alieva1, R E Uzbekov

  • 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. irina_alieva@belozersky.msu.ru

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Summary

This review categorizes centrosome proteins by function, including microtubule nucleation and cell cycle control. It presents a structural-temporal classification and interconnection scheme for these vital protein complexes.

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Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Centrosomes are crucial microtubule-organizing centers in animal cells.
  • Centrosome proteins perform diverse roles in cell division and structure.

Purpose of the Study:

  • To review current knowledge of centrosome protein functions.
  • To present a novel classification and interconnection scheme for centrosomal proteins.

Main Methods:

  • Literature review of contemporary research on centrosome proteins.
  • Analysis and synthesis of functional groupings of centrosome proteins.
  • Development of a structural-temporal classification system.

Main Results:

  • Centrosome proteins are grouped into functional categories: microtubule-nucleating, microtubule-anchoring, centriole-duplication, cell cycle control, primary cilia growth regulation, and cytokinesis regulation.
  • A structural-temporal classification of centrosomal proteins is proposed.
  • A scheme illustrating the interconnections between different centrosomal protein complexes is presented.

Conclusions:

  • This organized review provides a comprehensive framework for understanding centrosome protein organization and function.
  • The proposed classification aids in deciphering the complex regulatory networks governing centrosome biology.