Hydroxyethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial)

Area of Science:

• Cardiology
• Anesthesiology
• Biochemistry

Background:

• Ringer solution is the standard prime solution for cardiopulmonary bypass.
• Hydroxyethyl starch (HES) 130-0.4 is a potential alternative prime solution.
• HES solutions are indispensable for cardio-pulmonary bypass applications.

Purpose of the Study:

• To compare Ringer solution with HES 130-0.4 as a prime solution for cardiopulmonary bypass.
• To evaluate the effects of HES 130-0.4 on coagulation parameters and platelet counts.
• To assess the safety and efficacy of HES 130-0.4 in CABG surgery.

Main Methods:

• 140 patients undergoing Coronary Artery Bypass Graft (CABG) surgery were enrolled.
• Group 1 received Ringer solution as prime solution.
• Group 2 received HES 130-0.4 as prime solution.

Main Results:

• Postoperative INR, urea, and creatinine levels differed significantly between groups.
• Blood urea and creatinine levels were higher in the HES group at 12 and 24 hours.
• Platelet count was significantly higher in the HES group at 24 hours (p=0.001).
• HES 130-0.4 did not negatively affect INR, platelet count, transfusion needs, or drainage.

Conclusions:

• HES 130-0.4 is a viable alternative colloidal prime solution for cardiopulmonary bypass.
• HES 130-0.4 can be used alone or mixed with crystalloids.
• HES 130-0.4 demonstrates a favorable safety profile in CABG procedures.