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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Published on: January 26, 2019
[Spanish multidisciplinary consensus on the prevention of respiratory syncytial virus infection in children]
J Figueras Aloy1, J López Sastre, C Medrano López
1Sociedad Española de Neonatología (SEN), Spain. JFIGUER@clinic.ub.es
Insights
Spanish experts reached consensus on 48 of 57 recommendations for preventing respiratory syncytial virus (RSV) infections in children. These guidelines provide a framework for pediatric care until new evidence emerges.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Context:
- Feasible interventions for preventing respiratory syncytial virus (RSV) infection exist in Spanish clinical practice.
- These include hygienic measures and palivizumab immunoprophylaxis.
- Different pediatric specialties may perceive the problem and appropriate actions differently.
Purpose:
- To establish a Spanish multidisciplinary consensus on preventing RSV infection.
- Involved key pediatric scientific societies: SNS, SSPC, SSPP, and SSHPO.
Summary:
- A modified Delphi consensus method was employed over two rounds.
- A Scientific Committee and an Expert Panel of 77 specialists participated.
- Consensus was achieved on 48 out of 57 preventive recommendations.
Impact:
- The study generated a list of anti-RSV prophylactic recommendations rated by professional consensus.
- These recommendations serve as a valid guide for clinical practice.
- The findings highlight areas of agreement and disagreement among experts, informing future research and guideline development.
Background:
A certain degree of feasibility exists in Spanish clinical practice with respect to interventions performed to prevent paediatric respiratory infection by RSV, including hygienic measures and intramuscular immunoprophylaxis with palivizumab. This task involves different paediatric specialties that may have a different perception of the magnitude of the problem and different professional criteria regarding the most appropriate actions.
Objectives:
To develop Spanish multidisciplinary consensus on preventing infection by RSV with the participation of the paediatric scientific societies involved (SNS, SSPC, SSPP and SSHPO).
Methods:
Delphi Consensus modified in two rounds was used. The study was conducted in four phases: 1) constitution of a multidisciplinary Scientific Committee at the recommendation of the scientific entities participating in the study, for bibliographic review and submission of the recommendations to discussion; 2) constitution of an Expert Panel with 77 speciality representatives; 3) postal survey organised in two rounds and intermediate processing of opinions and issuing of a report for the panellists, and 4) discussion of the results in a meeting of the Scientific Committee.
Results:
Consensus was reached on 48 of the 57 preventive recommendations analysed. With respect to the 9 remaining issues, no consensus was reached, due to differences in professional opinion and the absence of established criteria among the majority of the experts. Only in 3 recommendations was the opinion of the experts associated with the speciality of origin.
Conclusions:
A list of anti-RSV prophylactic recommendations was submitted, rated in accordance with the degree of professional consensus on which they were based. These can be considered valid until such time as new scientific information emerges that warrants a review thereof.
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