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Related Experiment Video

Updated: Jul 3, 2026

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization
05:45

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization

Published on: January 19, 2024

Cell growth patterns and lens geometry: a quantitative study from three-dimensional reconstructions.

R W Hendrix1, K Rubinson

  • 1Department of Developmental and Structural Biology, The Public Health Research Institute, New York, NY, USA.

Tissue & Cell
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

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Sea lamprey lens growth is exponential over five years, driven by anterior epithelial cell division and posterior mass recruitment. Cell geometry and position define distinct lens zones, with boundaries shifting as the lens grows.

Area of Science:

  • Developmental Biology
  • Comparative Anatomy
  • Ichthyology

Background:

  • Lens development and growth are crucial for vision.
  • Understanding cellular mechanisms driving organ growth provides insight into developmental processes.

Purpose of the Study:

  • To investigate the growth patterns of the sea lamprey (Petromyzon marinus) lens during its five-year larval stage.
  • To correlate cellular geometric parameters with cell position within the lens.
  • To develop a model for lens growth based on cellular behavior and zonal organization.

Main Methods:

  • Computer-assisted microscopy was used to reconstruct 25 whole lenses and 393 Golgi-impregnated cells.
  • Cellular geometric parameters (length, width, curvature, surface, volume, shape) were analyzed.

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Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses
07:56

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Published on: May 3, 2016

Related Experiment Videos

Last Updated: Jul 3, 2026

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization
05:45

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization

Published on: January 19, 2024

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses
07:56

Sequential Application of Glass Coverslips to Assess the Compressive Stiffness of the Mouse Lens: Strain and Morphometric Analyses

Published on: May 3, 2016

  • Correlations between cell parameters and their position on the lens capsular perimeter were established.

    • Main Results:

    • Four distinct cellular zones (central anterior, germinative, transitional, cortical fiber) were identified based on cell geometry and position.
    • Lens growth was found to be exponential over the five-year period.
    • Anterior epithelium grows via cell division and growth; posterior mass grows via recruitment and cell growth.
    • Zonal boundaries shift outward as cells are incorporated into adjacent zones with growth.

    Conclusions:

    • Lens growth is a coupled process of anterior and posterior tissue expansion.
    • Cellular geometry and position are key determinants of lens zonation.
    • The study refutes the hypothesis of central cell migration in sea lamprey lens development.