Liver-kidney pathophysiological interrelationships in liver diseases

On the basis of several clinical and experimental researches, it is possible today to deepen the different mechanisms regarding kidney and liver relationships. However, the most studied field remains the renal function during liver disease. These alterations can be divided into: 1. Renal functional impairment is mainly considered due to hemodynamic derangement with a progressive decrease in peripheral vascular resistance (PVR) and an increase in cardiac output and rate, characteristic of hyperdynamic circulation, and outer cortex renal ischemia. Two principal forms of RFI characterize the hepatorenal syndrome (HRS) while in the first stage is based on the simple decrease in renal clearances with avid sodium retention. 2. Metabolic renal damage is principally due to abnormal serum levels of bile acids, bilirubin and perhaps toxic hepatic molecules which induce tubular dysfunction leading to RTA, of which type I, in the incomplete form, is the most common, varying between 30% and 50% of cases. It is mainly studied during cholestatic disease. 3. Organic renal impairment is principally based on immunological response to viral antigens and abnormal hepatic products which lead to the presence of immunocomplexes and cryoglobulins on the blood which tend to be deposited in the subendothelial and subepithelial glomerular areas, inducing complement activation, mesangial cell proliferation and monocyte-macrophage cell infiltration.