Confirming schizotypic personality configurations in hypothetically psychosis-prone university students

The personality features of hypothetically psychosis-prone (or schizotypic) subjects were examined. Schizotypic (n = 32) and control (n = 44) subjects were identified within a pool of 726 randomly ascertained nonclinical university students who had completed the Perceptual Aberration Scale (PAS) during a large-scale screening study. Approximately 4-6 months after the initial screening, the schizotypic and control subjects completed the Minnesota Multiphasic Personality Inventory (MMPI). Schizotypic subjects as a group displayed an average MMPI profile consistent with schizotypic personality features, whereas the control subjects did not. Moreover, multivariate profile analysis revealed that the schizotypic group MMPI profile differed significantly in shape from the control group profile. Finally, schizophrenia-related MMPI high-point codes were five times as prevalent among the PAS-identified schizotypic subjects as among the controls. The results suggest that the PAS identifies individuals who show schizotypic personality MMPI configurations and may carry a latent vulnerability for schizophrenia or, more broadly, psychosis.