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Promises and obstacles for the blockade of CD40-CD40L interactions in allotransplantation

Xian-Liang Li1, Séverine Ménoret, Brigitte Le Mauff

  • 1INSERM, U643, Nantes, 44093 France.

Transplantation
|July 16, 2008
PubMed

Although clinical trials using anti-CD40L mAb have been halted, blockade of CD40-CD40L interactions has given promising results in rodent and nonhuman primate models. Recently, new insights into the consequences of blocking CD40-CD40L interactions have led to the possibility of overcoming the thromboembolic complications previously associated with this strategy and may pave the way for successful tolerance induction. This mini review will address the issues relating to CD40-CD40L blockade in allotransplantation.

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