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Related Concept Videos

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Kidney Transplant II: Surgical Procedure

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Related Experiment Video

Updated: Jul 3, 2026

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

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Published on: June 10, 2025

Renal function impacts outcomes after intestinal transplantation.

Melissa J Watson1, Robert S Venick, Fady Kaldas

  • 1UCLA Department of Surgery, Los Angeles, CA, USA.

Transplantation
|July 16, 2008
PubMed
Summary

Renal dysfunction (RD) after intestinal transplantation (ITx) is common and linked to poor survival. Pre-transplant factors and high-dose immunosuppression predict RD, highlighting the need to preserve kidney function for better ITx outcomes.

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Last Updated: Jul 3, 2026

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

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08:39

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Published on: November 7, 2020

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Immunology

Background:

  • Renal dysfunction (RD) is linked to poor outcomes in solid organ transplantation.
  • However, RD after intestinal transplantation (ITx) has not been extensively studied.
  • This study analyzes renal function post-ITx and identifies predictors of RD.

Purpose of the Study:

  • To analyze renal function after intestinal transplantation.
  • To identify predictors of renal dysfunction in ITx recipients.
  • To determine the impact of RD on post-transplant survival.

Main Methods:

  • Retrospective analysis of 62 patients undergoing 68 ITx from 1991 to 2006.
  • Estimated glomerular filtration rate (eGFR) was compared to normal values.
  • Chi-square and log-rank tests identified predictors of RD (eGFR <75% of normal) and survival impact.

Main Results:

  • 16% of patients developed renal dysfunction post-ITx.
  • Predictors included preoperative low eGFR, ICU stay, and high-dose tacrolimus.
  • Low eGFR at 7, 28, and 365 days post-ITx predicted poor patient survival (P<0.05).

Conclusions:

  • This is the first detailed analysis of renal function after ITx.
  • Specific risk factors for early RD were identified.
  • RD is significantly associated with decreased long-term survival, emphasizing renal function preservation.