Related Experiment Video
Updated: Jul 3, 2026

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Improper renal dosing in long-term care facilities
Ali R Rahimi1, Klugh Kennedy, Misha Thomason
1SouthEastern Georgia Geriatrics, Savannah, GA 31419, USA.
Objectives:
With advancing age, physiologic changes occur that affect drug metabolism. Possibly the most predictable function decline in geriatric population is renal function.
Methods:
The prescribing habits of physicians and the attention given to patient renal function was investigated. Data was collected from two nursing facilities in southeastern Georgia.
Results:
Based on two models of prescribing habits and using logistic regression estimates, we concluded that physicians do not follow recommendations for dose adjustment of renally excreted medications in these two facilities.
Conclusion:
We recommend that physicians consider evaluating current medications and establishing a base line for renal function and degree of decline.
Related Concept Videos
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Dosing: Geriatric Patients
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Acute Kidney Injury V: Interprofessional Care