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Updated: Jul 3, 2026

BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain
Published on: May 26, 2023
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
Laurent Groc1, Daniel Choquet, Francis Chaouloff
1Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Université Bordeaux 2, Bordeaux 33077, France. laurent.groc@u-bordeaux2.fr
Abstract:
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.
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