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Updated: Jul 3, 2026
09:18
Spheroid Assay to Measure TGF-β-induced Invasion
Published on: November 16, 2011
Connective tissue growth factor (CTGF) and cancer progression
Chia-Yu Chu1, Cheng-Chi Chang, Ekambaranellore Prakash
1Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 100, Taiwan, ROC.
Journal of Biomedical Science
|July 16, 2008
Summary
Connective tissue growth factor (CTGF) influences cancer progression by affecting cell migration and angiogenesis. This review details CTGF
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Connective tissue growth factor (CTGF) is a CCN family protein involved in angiogenesis and tumor growth.
- CTGF expression is linked to tumor development and progression.
- CCN proteins regulate diverse cellular functions including cell division, migration, and apoptosis.
Purpose of the Study:
- To review the influence of CTGF on cancer cell biological behavior and progression.
- To highlight CTGF's regulation of protein signals and their mechanisms in cancer.
Main Methods:
- Literature review of studies on CTGF expression and cancer.
- Analysis of CTGF's role in cancer cell migration, invasion, angiogenesis, and anoikis.
- Examination of CTGF's regulatory mechanisms on protein signaling pathways.
Main Results:
- CTGF expression is associated with increased cancer cell migration, invasion, and angiogenesis.
- CTGF influences anoikis, a form of programmed cell death.
- CTGF regulates various protein signals critical for cancer progression.
Conclusions:
- CTGF plays a significant role in the biological behavior and progression of various cancers.
- Understanding CTGF's regulatory mechanisms can provide insights into cancer therapy.
- Further research into CTGF signaling pathways is warranted for therapeutic targeting.
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