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A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
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Spray-dried chitosan as a direct compression tableting excipient.

Dakshinamurthy Devanga Chinta1, Richard A Graves, Sarala Pamujula

  • 1Center for Nanomedicine and Drug Delivery, Xavier University of Louisiana, New Orleans, LA 70125-1098, USA.

Drug Development and Industrial Pharmacy
|July 16, 2008
PubMed
Summary

This study developed novel spray-dried chitosan-lactose granules as tableting excipients. These granules exhibited excellent flow properties and suitability for direct compression into floating tablets.

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Published on: January 22, 2015

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tableting excipients are crucial for drug formulation.
  • Chitosan and lactose are common excipients with unique properties.
  • Spray-drying is an effective method for granule preparation.

Purpose of the Study:

  • To prepare and evaluate a novel spray-dried tableting excipient using a chitosan-lactose mixture.
  • To investigate the effect of chitosan molecular weight and proportion on granule properties.
  • To assess the suitability of the prepared granules for direct compression into floating tablets.

Main Methods:

  • Three grades of chitosan (low, medium, high molecular weight) were used.
  • Chitosan and lactose were dissolved in aqueous solutions with citric acid and propranolol hydrochloride (model drug).
  • Granules were prepared using a laboratory spray drier and evaluated for physical, thermal, and tableting properties.

Main Results:

  • Granule bulk density decreased with increasing chitosan molecular weight.
  • Granules prepared with 1g of chitosan, regardless of molecular weight, exhibited the best flow properties (minimum Carr index of 11.1%).
  • Floating tablets formulated via direct compression showed 50% drug release within 30-35 minutes.

Conclusions:

  • Spray-dried chitosan-lactose granules are a promising novel excipient.
  • The developed granules possess excellent flowability, making them suitable for direct compression tableting.
  • The resulting floating tablets demonstrate effective drug release profiles.