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Updated: Jul 3, 2026
09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
[Pregnancy-associated breast cancer]
Marie Christin Eisenbrand1, Edward Wight, Uwe Güth
1Departement für Gynäkologie und Geburtshilfe, Universitätsspital Basel, Spitalstrasse 21, Basel.
Therapeutische Umschau. Revue Therapeutique
|July 16, 2008
Summary
Pregnancy-associated breast cancer (PABC) is rare, but diagnosis is challenging due to breast changes. Treatment options exist during pregnancy, and termination is not indicated.
Area of Science:
- Oncology
- Obstetrics & Gynecology
Context:
- Pregnancy-associated breast cancer (PABC) is a rare condition with an incidence of 1:3000.
- Physiological changes in the breast during pregnancy complicate the interpretation of clinical findings, ultrasound, and mammography.
- Diagnostic delays are common in PABC.
Purpose:
- To outline the diagnostic and therapeutic challenges of PABC.
- To inform about management strategies for PABC during pregnancy.
Summary:
- Mastectomy and axillary lymphonodectomy are standard surgical treatments.
- Breast-conserving surgery followed by postpartum radiotherapy is an option in the third trimester.
- Chemotherapy is relatively safe in the second and third trimesters, while radiotherapy, hormonal therapy, and trastuzumab are contraindicated.
Impact:
- Maternal prognosis is not influenced by pregnancy, thus termination is not indicated.
- Interdisciplinary and specialized center care is recommended for optimal management of PABC patients.
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