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A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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Flow parameters associated with hydrodynamic cell injury.

M A Garcia-Briones1, J J Chalmers

  • 1Department of Chemical Engineering, Ohio State University, 140 W 19th Ave, Columbus, OH 43210, USA.

Biotechnology and Bioengineering
|November 5, 1994
PubMed
Summary

New parameters quantify cell-damaging flows from bubble collapse. The state of stress and flow classification parameter R(D) identify regions with high hydrodynamic stresses and elongation, crucial for understanding cellular damage mechanisms.

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Area of Science:

  • Fluid dynamics
  • Biophysics
  • Cell biology

Background:

  • Flows with high stress can damage animal cells.
  • Analyzing these damaging flows requires specific parameters.

Purpose of the Study:

  • To propose and analyze two new parameters for characterizing cell-damaging flows.
  • To identify regions of high stress and elongation during bubble collapse.

Main Methods:

  • Defining the state of stress using the second invariant of the stress tensor.
  • Utilizing the flow classification parameter R(D) related to stress relaxation.
  • Analyzing the flow generated by a 1.7-mm bubble collapsing at a liquid interface.

Main Results:

  • The state of stress parameter effectively characterizes hydrodynamic stresses.
  • The R(D) parameter indicates the potential for stress relaxation.
  • Specific flow regions with high stress and elongation were identified during bubble collapse.

Conclusions:

  • The proposed parameters provide a robust method for analyzing cell-damaging flows.
  • These parameters are valuable for predicting and mitigating cellular damage in various fluid environments.