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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Controlling enzyme-catalyzed regioselectivity in sugar ester synthesis.

J O Rich1, B A Bedell, J S Dordick

  • 1Department of Chemical and Biochemical Engineering, and Center for Biocatalysis and Bioprocessing, University of Iowa, Iowa City, IA 52242, USA.

Biotechnology and Bioengineering
|March 5, 1995
PubMed
Summary

Researchers explored enzyme-catalyzed regioselectivity in sucrose acylation. They found that solvent hydrophobicity and vinyl ester chain length rationally control enzyme reactions, offering new insights into biocatalysis.

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