Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interventions and functional brain imaging.

A P Yudd1, R L Van Heertum, J C Masdeu

  • 1Department of Radiology, St. Vincent's Hospital Medical Center, New York, NY 10011.

Seminars in Nuclear Medicine
|April 1, 1991
PubMed
Summary

Assessing regional cerebral blood flow (rCBF) with acetazolamide-augmented SPECT helps differentiate vascular issues from neuronal loss in cerebrovascular disease. This stress test reveals diminished flow reserve missed by resting studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Ears of the Lynx" MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia.

AJNR. American journal of neuroradiology·2019
Same author

Intracranial arteries in individuals with the elastin gene hemideletion of Williams syndrome.

AJNR. American journal of neuroradiology·2013
Same author

Midbrain presynaptic dopamine tone predicts sustained and transient neural response to emotional salience in humans: fMRI, MEG and FDOPA PET.

Molecular psychiatry·2012
Same author

EFNS guidelines on the use of neuroimaging in the management of motor neuron diseases.

European journal of neurology·2010
Same author

Forceps minor region signal abnormality "ears of the lynx": an early MRI finding in spastic paraparesis with thin corpus callosum and mutations in the spatacsin gene (SPG11) on chromosome 15.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2008
Same author

Fatigue in multiple sclerosis is associated with the disruption of frontal and parietal pathways.

Multiple sclerosis (Houndmills, Basingstoke, England)·2008

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Regional cerebral blood flow (rCBF) assessment is crucial for evaluating cerebrovascular disease.
  • Resting rCBF studies have limitations, potentially missing diminished vascular reserve or showing decreased flow due to diaschisis/neuronal loss with intact vasculature.

Purpose of the Study:

  • To review the utility of stress single photon emission computed tomography (SPECT) using vasodilatory stimuli.
  • Specifically, to discuss acetazolamide-augmented SPECT in evaluating cerebrovascular disease.

Main Methods:

  • Review of studies utilizing acetazolamide (Diamox) as a vasodilatory stimulus.
  • Application of single photon emission computed tomography (SPECT) for rCBF measurement under stress conditions.

Related Experiment Videos

Main Results:

  • Acetazolamide-augmented SPECT can differentiate between diminished cerebrovascular reserve and conditions like diaschisis or selective neuronal loss.
  • This stress-testing approach provides a more comprehensive evaluation than resting rCBF studies alone.

Conclusions:

  • Acetazolamide-augmented SPECT is a valuable tool for assessing cerebrovascular disease.
  • It enhances the diagnostic capability of SPECT by unmasking cerebrovascular dysfunction not evident at rest.