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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

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Related Experiment Video

Updated: Jul 3, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

Endothelial dysfunction in haemophilia patients.

M T Sartori1, F Bilora, E Zanon

  • 12nd Chair Internal Medicine, Department of Medical and Surgical Sciences, University of Padua, Padova, Italy. mtsart@unipd.it

Haemophilia : the Official Journal of the World Federation of Hemophilia
|July 16, 2008
PubMed
Summary

Haemophilia patients exhibit significant endothelial dysfunction, characterized by impaired flow-mediated dilation (FMD) and reduced tissue plasminogen activator (t-PA) release. Cardiovascular risk factors are prevalent, and viral infections may contribute to vascular damage.

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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Related Experiment Videos

Last Updated: Jul 3, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Vascular Biology

Background:

  • Haemophilia patients are susceptible to cardiovascular diseases, despite their clotting defect.
  • The complete impact of haemophilia on atherosclerosis and its complications is not fully understood.
  • Endothelial dysfunction is a key early event in atherosclerosis.

Purpose of the Study:

  • To evaluate cardiovascular risk factors in middle-aged haemophilia patients.
  • To assess for the presence of endothelial dysfunction in this population.
  • To explore potential contributing factors to vascular damage.

Main Methods:

  • Studied 40 haemophilia patients (A and B) and 40 healthy controls.
  • Measured flow-mediated dilation (FMD) and carotid ultrasound intima-media thickness (IMT).
  • Assessed cardiovascular risk factors, including lipids, glucose, and inflammatory markers; viral infections were also screened.

Main Results:

  • 87.5% of patients had at least one cardiovascular risk factor; 47.5% had two or more.
  • All patients demonstrated significantly impaired FMD, with reduced t-PA release in 70%.
  • Impaired FMD was more pronounced in patients with chronic viral hepatitis and/or HIV infection.

Conclusions:

  • Haemophilia patients exhibit endothelial dysfunction, evidenced by impaired FMD and t-PA release.
  • Cardiovascular risk factors are common in this cohort.
  • Chronic viral infections may play a role in the observed endothelial damage.