Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial Transcriptomic Landscape of Canine Oral Squamous Cell Carcinoma.

Molecular carcinogenesis·2025
Same author

Alteration in expression and subcellular localization of the androgen receptor- regulated FAM111A protease is associated with emergence of castration resistant prostate cancer.

Neoplasia (New York, N.Y.)·2025
Same author

A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death.

Cell chemical biology·2024
Same author

Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer.

Nature communications·2024
Same author

Post-death Vesicles of Senescent Bone Marrow Mesenchymal Stromal Polyploids Promote Macrophage Aging and Breast Cancer.

bioRxiv : the preprint server for biology·2024
Same author

KSHV vIL-6 enhances inflammatory responses by epigenetic reprogramming.

PLoS pathogens·2023

Related Experiment Video

Updated: Jul 3, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

MicroRNAs and prostate cancer.

Xu-Bao Shi1, Clifford G Tepper, Ralph W Devere White

  • 1Department of Urology, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA.

Journal of Cellular and Molecular Medicine
|July 16, 2008
PubMed
Summary

MicroRNAs (miRNAs) are implicated in prostate cancer (CaP) progression. Aberrantly expressed miRNAs function as oncogenes or tumor suppressors, offering potential biomarkers and therapeutic targets for CaP treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (CaP) is a leading cause of cancer death in men.
  • Androgen ablation therapy resistance leads to aggressive, untreatable CaP.
  • Mechanisms driving CaP progression, especially to androgen independence, are poorly understood.

Purpose of the Study:

  • To review current findings on aberrantly expressed microRNAs (miRNAs) in prostate cancer.
  • To explore the roles of CaP-related miRNAs as oncogenes and tumor suppressors.
  • To investigate the link between miRNA regulation, androgen signaling, and CaP progression.

Main Methods:

  • Literature review of studies on microRNAs in prostate cancer.
  • Analysis of characterized CaP-related miRNAs and their mRNA targets.

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Related Experiment Videos

Last Updated: Jul 3, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)
08:30

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR (qPCR)

Published on: May 16, 2012

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

  • Examination of evidence linking miRNA regulation to androgen signaling.

    • Main Results:

    • Several microRNAs (miRNAs) are aberrantly expressed in prostate cancer (CaP).
    • Five CaP-related miRNAs are characterized: three oncogenic, two tumor-suppressive.
    • Oncogenic miRNAs downregulate apoptosis genes; tumor suppressor miRNAs target proliferation genes.
    • CaP-related miRNAs are regulated by androgen signaling, potentially driving androgen independence.

    Conclusions:

    • MicroRNAs (miRNAs) play critical roles in prostate cancer (CaP) pathogenesis.
    • CaP-related miRNAs demonstrate oncogenic or tumor-suppressive functions.
    • These miRNAs are promising biomarkers and potential therapeutic targets for CaP treatment.