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Increased risk for coeliac disease in paediatric patients with migraine

F Alehan1, F Ozçay, I Erol

  • 1Divisions of Child Neurology, Baskent University of Medicine, Ankara, Turkey. falehan@hotmail.com

Cephalalgia : an International Journal of Headache
|July 16, 2008
PubMed

Insights

This study found a higher prevalence of coeliac disease (CD) markers in children with migraine. These findings suggest a potential link between paediatric migraine and CD.

Area of Science:

  • Neurology
  • Gastroenterology
  • Immunology

Background:

  • Migraine is a common neurological disorder in children.
  • Coeliac disease (CD) is an autoimmune disorder triggered by gluten.
  • The association between paediatric migraine and CD requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of coeliac disease (CD) in paediatric patients experiencing migraine.
  • To assess the presence of serum tissue transglutaminase IgA (tTGA) antibodies in children with migraine.

Main Methods:

  • Serum tTGA antibody and IgA levels were measured in 73 paediatric migraine patients and 147 controls.
  • Patients with positive tTGA antibodies underwent duodenal biopsy for histological confirmation.
  • Prevalence rates were compared between the study and control groups.

Main Results:

  • Four (5.5%) paediatric migraine patients and one (0.6%) control subject had positive tTGA antibody titres (P < 0.05).
  • Three migraine patients with positive tTGA antibodies showed normal duodenal histology, indicating potential CD.
  • One patient in each group declined biopsy.

Conclusions:

  • A higher prevalence of tTGA antibodies was observed in paediatric migraine patients compared to controls.
  • The findings suggest a potential association between migraine and coeliac disease in children.
  • Further research is warranted to elucidate the relationship between these conditions.

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