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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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Multiway modeling and analysis in stem cell systems biology.

Bülent Yener1, Evrim Acar, Pheadra Aguis

  • 1Department of Computer Science, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. yener@cs.rpi.edu

BMC Systems Biology
|July 16, 2008
PubMed
Summary

Systems biology uses tensor analysis to model stem cell differentiation. This approach reveals stimulus-dependent gene expression and how mechanical strain affects osteogenic differentiation in human mesenchymal stem cells.

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Area of Science:

  • Systems biology
  • Computational biology
  • Stem cell biology

Background:

  • Systems biology integrates multidisciplinary approaches to understand biological systems.
  • Stem cells offer therapeutic potential, making them key targets for systems biology analysis.
  • Multiway modeling, or tensor analysis, can analyze multimodal data for complex cellular behaviors like differentiation, unlike bimodal models.

Purpose of the Study:

  • To review the application of systems biology to stem cells.
  • To illustrate tensor analysis for modeling collagen-induced osteogenic differentiation of human mesenchymal stem cells (hMSCs).

Main Methods:

  • Applied Tucker1, Tucker3, and Parallel Factor Analysis (PARAFAC) tensor models.
  • Organized data into tensors representing protein/gene locus links, gene ontology categories, and osteogenic stimulants.
  • Structured DNA microarray data into tensors of gene IDs, osteogenic stimulus, and replicates.

Main Results:

  • Identified two distinct, stimulus-dependent sets of functionally related genes during hMSC osteogenic differentiation.
  • Demonstrated that tensile strain on a collagen I substrate accelerated osteogenic differentiation induced by a static collagen I substrate.

Conclusions:

  • Proposed gene- and protein-level models for stem cell transdifferentiation to osteoblasts.
  • Established tensor analysis methods as applicable to various stem cell differentiation models.
  • Laid the groundwork for mechanistic, hypothesis-driven studies in stem cell biology.