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Updated: Jul 3, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
Published on: March 3, 2016
The role of alphoid higher order repeats (HORs) in the centromere folding
Marija Rosandić1, Matko Gluncić, Vladimir Paar
1Department of Internal Medicine, University Hospital Rebro, University of Zagreb, Kispatićeva 12, 10000 Zagreb, Croatia. rosandic@hazu.hr
Abstract:
Understanding the folding of centromere DNA in the maximally condensed methaphase chromosome remains a basic challenge in cell biology. We propose here a set of structural models with a graphical presentation of alphoid higher order repeat (HOR) distribution in the centromere folding, based on the assumption of encryption key for microtubule-centromere interaction which arises from chromosome-specific crystal-like structure of HORs. Specific HOR leads to a characteristic geometrical pattern which may be responsible for individual microtubule to recognize a specific structure of centromere in each chromosome.
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