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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: Jul 3, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Human embryonic stem cells: emerging technologies and practical applications.

Lief E Fenno1, Leon M Ptaszek, Chad A Cowan

  • 1Stowers Medical Institute, Harvard Stem Cell Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, CPZN-4234, Boston, MA 02114, United States.

Current Opinion in Genetics & Development
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Human embryonic stem cells can become any cell type. New methods allow reprogramming somatic cells into pluripotent stem cells for disease modeling and therapies, enhancing stem cell applications.

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Derivation of Human Embryonic Stem Cells by Immunosurgery
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Derivation of Human Embryonic Stem Cells by Immunosurgery

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Related Experiment Videos

Last Updated: Jul 3, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Derivation of Human Embryonic Stem Cells by Immunosurgery
11:56

Derivation of Human Embryonic Stem Cells by Immunosurgery

Published on: December 13, 2007

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Genetic engineering

Background:

  • Human embryonic stem cells (hESCs) exhibit pluripotency, differentiating into all adult cell types.
  • Understanding stem cell biology is crucial for developing novel therapeutic applications.
  • Reprogramming differentiated somatic cells into induced pluripotent stem cells (iPSCs) is a significant advancement.

Purpose of the Study:

  • To review novel technologies in stem cell biology.
  • To discuss advancements in understanding stem cell pluripotency and differentiation.
  • To highlight the potential of iPSCs for disease modeling and cell-based therapies.

Main Methods:

  • Review of recent scientific literature on stem cell biology and genetic manipulation techniques.
  • Description of reprogramming methods for generating induced pluripotent stem cells.
  • Analysis of new genetic engineering tools for stem cell modification.

Main Results:

  • Terminally differentiated human somatic cells can be reprogrammed into pluripotent cells functionally equivalent to hESCs.
  • Novel genetic manipulation techniques simplify gene modification in stem cells.
  • Significant progress has been made in understanding the fundamental biology of stem cell pluripotency and differentiation.

Conclusions:

  • Induced pluripotent stem cells offer a promising substrate for developing future disease models and cell-based therapies.
  • Advances in stem cell technology and genetic manipulation are expanding the potential applications of stem cells.
  • Continued research into stem cell pluripotency and differentiation will drive innovation in regenerative medicine.