Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation.

Disease models & mechanisms·2026
Same author

Prevalence of Antibodies to Japanese Encephalitis Virus and Severe Fever with Thrombocytopenia Syndrome Virus in Wild Boars Captured Across Different Locations in Toyama Prefecture, Japan.

Viruses·2025
Same author

Genome epidemiological and seroepidemiological study of the COVID-19 cluster in the nursing home.

Japanese journal of infectious diseases·2025
Same author

Inducible NMDA receptor knockdown reveals a maintenance phase in dendritic refinement of barrel cortex neurons.

iScience·2025
Same author

Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein.

eLife·2025
Same author

Development of neutralization tests using single-round infectious particles and cytopathic effect as an alternative method for measuring antibody titers against Japanese encephalitis virus in national epidemiological surveillance program of vaccine-preventable diseases in Japan.

Journal of virological methods·2025

Related Experiment Video

Updated: Jul 3, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
14:01

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Mouse germ cell development during embryogenesis.

Yumiko Saga1

  • 1Division of Mammalian Development, National Institute of Genetics, Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka 411-8540, Japan. ysaga@lab.nig.ac.jp

Current Opinion in Genetics & Development
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

This review details mouse germ cell development, focusing on Blimp1, Nanos2, and Nanos3 proteins. These key regulators control germ cell specification, survival, and sex-specific differentiation during embryogenesis.

More Related Videos

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Related Experiment Videos

Last Updated: Jul 3, 2026

Isolation and Derivation of Mouse Embryonic Germinal Cells
14:01

Isolation and Derivation of Mouse Embryonic Germinal Cells

Published on: October 22, 2009

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells
12:06

Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Published on: January 11, 2019

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Germ cell development is crucial for reproduction.
  • Distinguishing germ cells from somatic cells is a fundamental developmental process.
  • Key regulatory proteins orchestrate germ cell fate and differentiation.

Purpose of the Study:

  • To review the process of germ cell development in mice.
  • To highlight the functions of Blimp1, Nanos2, and Nanos3 proteins.
  • To explain the roles of these proteins in germ cell specification and differentiation.

Main Methods:

  • Literature review of germ cell development studies.
  • Focus on molecular mechanisms involving key proteins.
  • Analysis of gene expression and protein function data.

Main Results:

  • Blimp1 is essential for early primordial germ cell (PGC) specification.
  • Nanos3 prevents PGC apoptosis during migration.
  • Nanos2 promotes male germ cell development by suppressing female fate.

Conclusions:

  • Blimp1, Nanos2, and Nanos3 are critical regulators of mouse germ cell development.
  • These proteins control distinct stages from specification to sex-specific differentiation.
  • Understanding these pathways is key to reproductive biology research.