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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Jul 3, 2026

Dissection and Isolation of Murine Glia from Multiple Central Nervous System Regions
08:00

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Published on: June 4, 2020

Glial cells in ALS: the missing link?

Elsa Raibon1, Lisa Marie Todd, Thomas Möller

  • 1Department of Neurology, University of Washington, Box 356465, 1959 NE Pacific Street, Seattle, WA 98195, USA.

Physical Medicine and Rehabilitation Clinics of North America
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease affecting 8 in 100,000 people globally. Currently, there is no known cure for ALS, and its cause remains unknown.

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Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is the most common motor neuron disease.
  • First described in the 19th century, ALS affects approximately 8 per 100,000 individuals worldwide annually.
  • Familial forms account for 5-10% of cases, with onset typically peaking in the seventh decade and a slight male predominance.

Purpose of the Study:

  • To provide a comprehensive overview of Amyotrophic Lateral Sclerosis (ALS).
  • To highlight key epidemiological and clinical characteristics of the disease.

Main Methods:

  • Literature review and synthesis of existing epidemiological data on ALS.
  • Analysis of historical context and naming conventions associated with the disease.

Main Results:

  • ALS is characterized by rapid motor neuron loss, leading to death within 3-5 years of symptom onset.
  • Incidence rates and demographic factors (age, sex) associated with ALS have been documented.
  • The etiology of ALS remains unidentified, and no definitive cure is currently available.

Conclusions:

  • Amyotrophic lateral sclerosis is a devastating neurodegenerative disorder with a significant impact on public health.
  • Further research is critical to understand the unknown causes of ALS and develop effective therapies.