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Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
What is the Immune System?01:38

What is the Immune System?

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Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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Related Experiment Video

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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

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Published on: April 11, 2019

Immunological tolerance and the autoimmune response.

A J S Davies1

  • 1University of London, Senate House, Malet Street, London, WC1E 7HU, United Kingdom. tony.davies@blueyonder.co.uk

Autoimmunity Reviews
|July 16, 2008
PubMed
Summary

Masked autoantibodies challenge human self-recognition. This suggests self-recognition is an active process, not solely based on eliminating self-reactive cells, impacting our understanding of immunity.

Area of Science:

  • Immunology
  • Human Biology
  • Autoimmunity

Background:

  • The discovery of masked autoantibodies by McIntire and Faulk raises questions about established theories of self-recognition.
  • Understanding self-recognition is crucial for comprehending immune system function and autoimmune diseases.

Purpose of the Study:

  • To review the discovery of masked autoantibodies in the context of human interaction with foreign agents.
  • To explore the implications of this discovery for the mechanisms of self-recognition and immune responses.

Main Methods:

  • Literature review and conceptual analysis.
  • Integration of findings on masked autoantibodies with concepts of innate immunity, microchimaerism, and infectious diseases.

Main Results:

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  • Masked autoantibodies challenge the traditional view of self-recognition.
  • The capacity to respond to foreign agents may not be exclusively defensive.

Conclusions:

  • Self-recognition is likely an active, ongoing process.
  • Immune responses are not solely dependent on the elimination of self-reactive capacities.
  • This paradigm shift impacts understanding of autoimmunity and immune tolerance.