Related Experiment Video
Updated: Jul 3, 2026

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016
The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells
J S Brugge1, A F Purchio, R L Erikson
1Department of Pathology, University of Colorado Medical Center, Denver, Colorado 80262, USA.
Abstract:
Poly(A)-containing cytoplasmic RNA and nuclear RNA from Rous sarcoma virus (RSV)-induced hamster tumor cells was fractionated on sucrose density gradients and hybridized with a [3H]cDNA probe to determine the size distribution of virus-specific RNA. One size class of viral RNA sedimenting at 21 S was detected in cytoplasmic poly(A)-containing RNA. Nuclear RNA contained three species of virus-specific RNA sedimenting at 47, 35, and 21 S. Sedimentation of nuclear RNA under denaturing conditions did not change this size distribution.
Related Concept Videos
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Rabies

