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Related Experiment Video

Updated: Jul 3, 2026

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Published on: September 29, 2019

Polymyxins revisited.

David Landman¹, Claudiu Georgescu, Don Antonio Martin

¹Division of Infectious Diseases, SUNY-Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

Clinical Microbiology Reviews

|July 16, 2008

Summary

This summary is machine-generated.

Polymyxins are crucial for treating multidrug-resistant gram-negative infections. Further research is needed to optimize dosing and in vitro testing for these vital antibiotics.

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Last Updated: Jul 3, 2026

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

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Published on: September 29, 2019

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Published on: April 18, 2019

Area of Science:

Microbiology
Infectious Diseases
Pharmacology

Background:

The rise of multidrug-resistant gram-negative bacilli has led to a resurgence in the use of polymyxins, antibiotics previously limited by toxicity concerns.
Polymyxins are now essential for treating infections caused by resistant pathogens like Pseudomonas aeruginosa and Acinetobacter baumannii.
Despite their renewed importance, optimal dosing strategies and reliable in vitro susceptibility testing methods for polymyxins require further investigation.

Purpose of the Study:

To review the current role and challenges associated with polymyxin use in clinical practice.
To highlight the need for standardized in vitro testing and established breakpoints for polymyxins.
To discuss the clinical efficacy and safety of polymyxins in comparison to other antibiotic classes.

Main Methods:

Review of contemporary clinical studies and surveillance data on polymyxin usage.
Analysis of in vitro susceptibility testing methodologies and their reliability.
Evaluation of clinical outcomes and toxicity profiles in patients treated with polymyxins.

Main Results:

Polymyxin therapy for multidrug-resistant infections shows comparable clinical response and toxicity rates to carbapenem therapy for susceptible infections.
While most studies report high susceptibility rates, the emergence of polymyxin-resistant strains is a growing concern.
Polymyxins have established a significant role in managing hospital-acquired infections.

Conclusions:

Polymyxins are indispensable agents for treating infections caused by multidrug-resistant gram-negative bacteria.
Further research into optimal dosing and standardized in vitro diagnostics is critical for maximizing polymyxin efficacy and safety.
Continued investigation into polymyxin use will ensure their sustained clinical utility against evolving resistant pathogens.