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Related Experiment Video

Updated: Jul 3, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

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Published on: April 14, 2014

Optical coherence tomography in neuromyelitis optica.

Jérôme de Seze1, Frederic Blanc, Luc Jeanjean

  • 1Department of Neurology, Strasbourg University, Hôpital Civil, 1 Place de l'Hôpital, BP 426, 67091 Strasbourg CEDEX, France. jerome.de.seze@chru-strasbourg.fr

Archives of Neurology
|July 16, 2008
PubMed
Summary

Optical coherence tomography (OCT) effectively measures axonal loss in Neuromyelitis Optica (NMO) by showing reduced retinal nerve fiber layer thickness, correlating with disease severity.

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Area of Science:

  • Neuroimmunology
  • Ophthalmology

Background:

  • Neuromyelitis Optica (NMO) is a severe inflammatory demyelinating disease affecting the optic nerves and spinal cord.
  • Current clinical follow-up lacks a reliable marker for assessing NMO disease severity and axonal damage.

Purpose of the Study:

  • To evaluate Optical Coherence Tomography (OCT) as a potential biomarker for axonal loss in NMO.
  • To determine the correlation between OCT findings and clinical measures of disability in NMO patients.

Main Methods:

  • A cross-sectional study involving 35 NMO patients and 15 healthy controls.
  • Comprehensive ophthalmologic examinations including OCT, visual acuity, visual fields, and visual evoked potentials.
  • Assessment of Expanded Disability Status Scale (EDSS) scores, excluding visual data.

Main Results:

  • Patients with NMO exhibited significantly reduced retinal nerve fiber layer thickness on OCT compared to controls (P < .001).
  • OCT results showed strong correlation with visual field testing and EDSS scores (P < .001).
  • Weak correlations were observed between OCT and visual acuity/visual evoked potential latencies; no correlation with age, sex, or disease duration.

Conclusions:

  • Optical Coherence Tomography (OCT) is a sensitive tool for detecting axonal damage in Neuromyelitis Optica (NMO).
  • OCT findings correlate well with established measures of visual function and overall disease severity (EDSS).
  • OCT shows promise as a non-invasive biomarker for monitoring NMO progression and disability.