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Related Concept Videos

The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
The Contractile Ring02:15

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

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Related Experiment Video

Updated: Jul 3, 2026

Aortic Ring Assay
09:12

Aortic Ring Assay

Published on: November 24, 2009

Kayser-Fleischer ring.

J C Suvarna1

  • 1Department of Pediatrics, Seth GS Medical College and KEM Hospital, Mumbai, India. crsuvarna@mtnl.net.in

Journal of Postgraduate Medicine
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

The Kayser-Fleischer (K-F) ring, caused by copper deposition, is a key indicator for Wilson

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Area of Science:

  • Ophthalmology
  • Hepatology
  • Genetics

Background:

  • Kayser-Fleischer (K-F) rings are a clinical sign associated with Wilson's disease (WD).
  • These rings result from copper deposition in the Descemet's membrane at the sclero-corneal junction.
  • While historically considered pathognomic for WD, K-F rings can also appear in other hepatic conditions and with intraocular copper foreign bodies.

Purpose of the Study:

  • To highlight the diagnostic significance of K-F rings in Wilson's disease.
  • To emphasize the role of K-F rings in early detection and management of WD.
  • To explore the correlation of K-F rings with disease severity and treatment compliance.

Main Methods:

  • Clinical observation and examination for K-F rings.
  • Correlation of K-F ring presence/absence with WD diagnosis.
  • Monitoring K-F ring changes in relation to treatment efficacy and patient compliance.
  • Assessment of K-F ring detection in relatives of WD patients.

Main Results:

  • K-F rings can be detected in pre-symptomatic Wilson's disease cases, enabling earlier diagnosis.
  • The presence, disappearance, and reappearance of K-F rings correlate with disease severity and treatment adherence.
  • K-F ring detection is crucial for screening first-degree relatives of individuals with Wilson's disease.

Conclusions:

  • Kayser-Fleischer rings are valuable diagnostic and monitoring tools for Wilson's disease.
  • Early detection of K-F rings facilitates timely intervention and management of WD.
  • Screening for K-F rings in family members is essential for comprehensive WD management.