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The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

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Updated: Jul 3, 2026

Aortic Ring Assay

Aortic Ring Assay

Published on: November 24, 2009

Kayser-Fleischer ring.

¹Department of Pediatrics, Seth GS Medical College and KEM Hospital, Mumbai, India. crsuvarna@mtnl.net.in

Journal of Postgraduate Medicine

|July 16, 2008

Summary

This summary is machine-generated.

The Kayser-Fleischer (K-F) ring, caused by copper deposition, is a key indicator for Wilson

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Area of Science:

Ophthalmology
Hepatology
Genetics

Background:

Kayser-Fleischer (K-F) rings are a clinical sign associated with Wilson's disease (WD).
These rings result from copper deposition in the Descemet's membrane at the sclero-corneal junction.
While historically considered pathognomic for WD, K-F rings can also appear in other hepatic conditions and with intraocular copper foreign bodies.

Purpose of the Study:

To highlight the diagnostic significance of K-F rings in Wilson's disease.
To emphasize the role of K-F rings in early detection and management of WD.
To explore the correlation of K-F rings with disease severity and treatment compliance.

Main Methods:

Clinical observation and examination for K-F rings.
Correlation of K-F ring presence/absence with WD diagnosis.
Monitoring K-F ring changes in relation to treatment efficacy and patient compliance.
Assessment of K-F ring detection in relatives of WD patients.

Main Results:

K-F rings can be detected in pre-symptomatic Wilson's disease cases, enabling earlier diagnosis.
The presence, disappearance, and reappearance of K-F rings correlate with disease severity and treatment adherence.
K-F ring detection is crucial for screening first-degree relatives of individuals with Wilson's disease.

Conclusions:

Kayser-Fleischer rings are valuable diagnostic and monitoring tools for Wilson's disease.
Early detection of K-F rings facilitates timely intervention and management of WD.
Screening for K-F rings in family members is essential for comprehensive WD management.