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Related Experiment Video

Updated: Jul 3, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Developmental perspectives on individual variation: implications for understanding nutritional needs.

Peter D Gluckman1, Alan S Beedle, Mark A Hanson

  • 1Liggins Institute, University of Auckland, Auckland, New Zealand.

Nestle Nutrition Workshop Series. Paediatric Programme
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Developmental plasticity and epigenetics explain biological variation better than genetics alone. Epigenetic biomarkers may predict developmental mismatch and enable early nutritional interventions for metabolic disorders.

Related Experiment Videos

Last Updated: Jul 3, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Area of Science:

  • Developmental biology
  • Epigenetics
  • Metabolic health

Background:

  • Genetic linkages to complex traits show limited explanatory power.
  • Developmental plasticity and epigenetic processes, influenced by environment, are key drivers of biological variation.
  • Early environmental cues can shape later-life adaptive responses through epigenetics.

Purpose of the Study:

  • To explore the clinical significance of epigenetic processes in development.
  • To understand how environmental factors influence epigenetic modifications and subsequent phenotypes.
  • To investigate the concept of developmental mismatch and its role in metabolic disorders.

Main Methods:

  • Review of experimental and clinical evidence linking environmental factors, epigenetics, and metabolic health.
  • Analysis of the role of epigenetic mechanisms in mediating life history and physiological changes.
  • Exploration of epigenetic biomarkers for predicting developmental mismatch.

Main Results:

  • Epigenetic mechanisms, influenced by early environmental cues, play a significant role in determining phenotype.
  • Developmental mismatch, arising from discordant fetal and postnatal environments, can lead to metabolic disorders.
  • Individual capacity to adapt to energetic environments is influenced by developmental epigenetic factors.

Conclusions:

  • Epigenetic processes are crucial for understanding biological variation and adaptation.
  • Developmental mismatch poses a risk for metabolic disorders.
  • Epigenetic biomarkers hold potential for identifying at-risk individuals and guiding interventions.