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Overview of Metabolism01:40

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
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Related Experiment Video

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
07:34

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Published on: March 14, 2013

Metabolic profiling.

Gerard T Berry1

  • 1Children's Hospital, Boston, MA, USA.

Nestle Nutrition Workshop Series. Paediatric Programme
|July 16, 2008
PubMed
Summary
This summary is machine-generated.

Garrod's concept of chemical individuality is key to understanding inherited metabolic diseases. Personalized nutritional therapy, guided by metabolic profiling, can prevent severe handicaps in affected infants.

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Last Updated: Jul 3, 2026

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)
07:34

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Published on: March 14, 2013

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Area of Science:

  • Biochemistry
  • Genetics
  • Metabolic Medicine

Background:

  • The concept of chemical individuality, introduced by Garrod in 1908, highlights unique metabolic differences.
  • Advances in gene expression and RNA/protein metabolism enhance understanding of inherited diseases.
  • Over 300 metabolic perturbations linked to genetic alterations have been identified.

Purpose of the Study:

  • To explore the evolution of metabolic medicine towards individualized nutritional therapeutics.
  • To emphasize the role of personalized nutrition in managing inherited metabolic disorders.
  • To highlight metabolic profiling as a tool for therapeutic planning and evaluation.

Main Methods:

  • Review of historical and modern principles in genetics and metabolism.
  • Analysis of identified metabolic perturbations and their genetic underpinnings.
  • Application of metabolic profiling for devising and assessing nutritional interventions.

Main Results:

  • Phenylketonuria treatment in 1953 demonstrated the efficacy of individualized nutritional therapy.
  • Early nutritional intervention can prevent cognitive and motor deficits in infants with inherited metabolic defects.
  • Metabolic profiling precisely measures analytes for tailored therapeutic plans.

Conclusions:

  • Metabolic medicine has entered a new phase of individualized nutritional therapeutics.
  • Personalized nutritional plans are crucial for patients with inherited metabolic disorders.
  • Metabolic profiling is essential for both devising and evaluating the efficacy of nutritional interventions.