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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Eosinophilic colitis in a patient with advanced transitional cell carcinoma of the bladder: a paraneoplastic
Mehtap Erkmen Uyar1, Cansel Turkay, Mustafa Erbayrak
1Department of Internal Medicine, Gastroenterology, and Radiology, Faculty of Medicine, Fatih University, Ankara, Turkey. mehtap94@yahoo.com
Abstract:
Eosinophilia associated with tumors is extremely rare. The exact underlying pathogenetic mechanisms are not well understood; limited data have been reported about granulocyte colony-stimulating factor and interleukin-5 in the development of eosinophilia. We report a patient with marked eosinophilia, leukocytosis, and eosinophilic colitis presenting with bloody stool. The subsequent diagnosis was advanced high-grade transitional cell carcinoma of the bladder. Leukocyte count, eosinophil count, and colonoscopic findings returned to normal after surgical removal of the tumor. To our knowledge, eosinophilic colonic infiltration as a manifestation of transitional cell bladder carcinoma has not been previously reported.
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