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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

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Related Experiment Video

Updated: Jul 3, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Multi-drug resistant Ewingella americana.

Syed Z Bukhari1, Waleed M Hussain, Mohammad I Fatani

  • 1Department of Microbiology, Hera General Hospital, PO Box 20865, Makkah, Kingdom of Saudi Arabia. zahidbukhari100@msn.com

Saudi Medical Journal
|July 16, 2008
PubMed
Summary

A rare case of pneumonia caused by multi-drug resistant Ewingella americana occurred in a young pilgrim in Saudi Arabia. This finding highlights the importance of identifying unusual pathogens in critically ill patients.

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Last Updated: Jul 3, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
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Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Pneumonia is a common cause of morbidity and mortality, especially in intensive care units.
  • Multi-drug resistant (MDR) pathogens pose a significant challenge in clinical settings.
  • Ewingella americana is a rare Gram-negative bacterium not commonly associated with pneumonia.

Observation:

  • A young Indonesian pilgrim, admitted to the Intensive Care Unit (ICU) in Makkah, Saudi Arabia, developed pneumonia following a severe head injury from a road traffic accident.
  • The patient presented with typical clinical signs and symptoms of pneumonia, supported by positive radiological findings.
  • Diagnostic investigations identified multi-drug resistant Ewingella americana as the causative agent.

Findings:

  • The case confirms Ewingella americana as a potential pathogen causing severe pneumonia in critically ill patients.
  • The isolate demonstrated multi-drug resistance, complicating treatment options.
  • This case underscores the need for broad-spectrum diagnostic approaches in ICU pneumonia.

Implications:

  • Highlights the emergence of Ewingella americana as a potential cause of hospital-acquired pneumonia, particularly in immunocompromised or critically ill individuals.
  • Emphasizes the importance of microbiological surveillance and timely identification of rare MDR pathogens in healthcare settings.
  • Suggests the need for updated treatment guidelines and diagnostic strategies to manage infections caused by unusual bacteria like Ewingella americana.