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[Clinical value of monophasic action potentials].
1Kardiologische Abteilung Stanford-Universität, Kalifornien.
Zeitschrift Fur Kardiologie
|April 1, 1991
Summary
Monophasic action potential (MAP) recording offers precise insights into cardiac electrophysiology, enabling direct measurement of repolarization and action potential duration. This technique aids in monitoring antiarrhythmic drugs and detecting myocardial ischemia.
Area of Science:
- Clinical electrophysiology
- Cardiac electrophysiology
- Cardiology
Context:
- Contact electrodes have improved monophasic action potential (MAP) recording safety and usability in clinical settings.
- MAP recording allows precise local activation determination and direct measurement of myocardial repolarization and action potential duration (APD).
Purpose:
- To highlight the advancements and clinical applications of monophasic action potential (MAP) recording.
- To demonstrate the utility of MAP recordings in assessing antiarrhythmic drug efficacy, myocardial ischemia, and arrhythmias like torsade de pointes.
Summary:
- Monophasic action potential (MAP) recording, enhanced by contact electrodes, provides precise measurements of local activation, action potential duration (APD), and myocardial repolarization.
- Simultaneous pacing and MAP recording allow for concurrent determination of APD and effective refractory periods (EPP).
- MAP recordings offer direct monitoring of antiarrhythmic drug effects, assessment of myocardial ischemia, and insights into arrhythmias such as torsade de pointes.
Impact:
- MAP recordings offer a more sensitive index of myocardial ischemia compared to conventional ECG.
- This technique provides new insights into the cycle-length-dependence of human APD and the relationship between ERP and APD.
- MAP recordings have aided in understanding the mechanisms of polymorphous ventricular tachycardia by identifying early after-depolarizations.