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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Polypoidal choroidal vasculopathy with drusen.

Daisuke Iwama¹, Akitaka Tsujikawa², Manabu Sasahara¹

¹Department of Ophthalmology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.

Japanese Journal of Ophthalmology

|July 16, 2008

Summary

Soft drusen are common in polypoidal choroidal vasculopathy (PCV) in Japanese patients, affecting one-third of eyes. Their presence appears to have minimal impact on the clinical course of PCV.

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Area of Science:

Ophthalmology
Retinal Diseases
Choroidal Neovascularization

Background:

Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration.
Drusen are yellowish deposits under the retina, commonly associated with macular degeneration.

Purpose of the Study:

To investigate the prevalence and clinical characteristics of drusen in eyes diagnosed with PCV.
To determine the association between drusen and PCV in a Japanese patient cohort.

Main Methods:

Retrospective review of 98 consecutive patients (102 eyes) with PCV.
Definition of drusen: presence of intermediate or large soft drusen (>or=63 microm) within 1500 microm of the foveal center.
Eyes with PCV and drusen were compared to eyes with PCV but no drusen.

Main Results:

Soft drusen were observed in the inner macula of 23% of eyes with PCV.
Overall, 33% of eyes with PCV had soft drusen in at least one eye.
No significant differences in patient characteristics or ocular manifestations were found between PCV eyes with and without drusen.

Conclusions:

Drusen are a frequent finding in eyes with PCV, particularly in Japanese populations.
The presence of drusen in PCV eyes appears to have a minor or negligible effect on the clinical progression of the disease.