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In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
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Construction of a pH-responsive artificial membrane fusion system by using designed coiled-coil polypeptides

Ayumi Kashiwada1, Kiyomi Matsuda, Toshihisa Mizuno

  • 1Department of Applied Molecular Chemistry, College of Industrial Technology, Nihon University, 1-2-1 Izumi-cho, Narashino, Chiba, Japan. a5kasiwa@cit.nihon-u.ac.jp

Chemistry (Weinheim an Der Bergstrasse, Germany)
|July 16, 2008
PubMed
Summary

Researchers designed a pH-responsive coiled-coil polypeptide to model viral fusion proteins. Acidic conditions promote coiled-coil formation, enhancing polypeptide-induced membrane fusion for artificial systems.

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