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Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

High-throughput study of phenytoin solid dispersions: formulation using an automated solvent casting method,

Valéry Barillaro1, Paolo P Pescarmona, Michiel Van Speybroeck

  • 1Laboratory for Pharmacotechnology and Biopharmacy, K.U. Leuven, Gasthuisberg O&N2, Herestraat 49, 3000 Leuven, Belgium.

Journal of Combinatorial Chemistry
|July 17, 2008
PubMed
Summary

A new high-throughput experimentation (HTE) method efficiently screens phenytoin solid dispersions for improved drug dissolution. Three optimized formulations achieved over 90% dissolution, validating the HTE approach for pharmaceutical development.

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Formation of Dispersible Taohong Siwu Tablets
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Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

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Last Updated: Jul 3, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Phenytoin is a poorly water-soluble drug, posing challenges for effective oral delivery.
  • Developing advanced formulations is crucial to enhance the bioavailability of such drugs.
  • High-throughput experimentation (HTE) offers a powerful tool for rapid screening of formulation components.

Purpose of the Study:

  • To develop and validate a high-throughput experimentation (HTE) method for studying phenytoin dissolution.
  • To screen multiple excipients and drug loadings for optimizing phenytoin solid dispersions.
  • To identify novel formulations with enhanced dissolution profiles.

Main Methods:

  • Preparation of 108 phenytoin solid dispersions using 12 excipients (7 polymers, 5 surfactants) at 10%, 20%, and 40% drug loadings.
  • Dissolution testing in simulated gastric fluid with 1% sodium lauryl sulfate.
  • Validation of HTE results through scale-up using a conventional solvent evaporation method.

Main Results:

  • Identification of three improved phenytoin formulations.
  • Achieved >90% drug dissolution within 30 and 60 minutes for optimized formulations.
  • Demonstrated reproducibility of HTE results at a larger scale, confirming method reliability.

Conclusions:

  • The developed HTE method is reliable and efficient for screening and optimizing poorly water-soluble drug formulations.
  • The study successfully identified promising solid dispersion formulations for phenytoin.
  • HTE significantly accelerates the discovery of enhanced drug delivery systems.