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Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration
Isobel A Scarisbrick1, Rachel Linbo, Alexander G Vandell
1Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. scarisbrick.isobel@mayo.edu
Abstract:
Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores determined at the time of serological sampling or at last clinical follow-up. Serum levels of KLK1 and KLK6 were elevated in MS patients (p
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