Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of American Society for Gastrointestinal Endoscopy standards for training in advanced endoscopy within dedicated advanced endoscopy fellowship programs.

Gastrointestinal endoscopy·2024
Same author

Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis.

Molecular & cellular proteomics : MCP·2022
Same author

Management of Early-Stage Esophageal Adenocarcinoma by Endoscopic Spray Cryotherapy in the Setting of Portal Hypertension With Varices.

ACG case reports journal·2020
Same author

Chronic Nausea and Vomiting: Sifting Through the Smoke and Weed.

The American journal of gastroenterology·2019
Same author

EGD core curriculum.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy·2018
Same author

A rare case of primary rectal squamous cell carcinoma diagnosed by endoscopic ultrasound.

Journal of gastrointestinal oncology·2017

Related Experiment Video

Updated: Jul 3, 2026

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi
12:33

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Herpes simplex virus and the alimentary tract.

Eric A Lavery1, Walter J Coyle

  • 1Division of Gastroenterology and Hepatology Scripps Clinic Torrey Pines, 10666 North Torrey Pines Road, N203, La Jolla, CA 92037, USA.

Current Gastroenterology Reports
|July 17, 2008
PubMed
Summary

Herpes simplex virus (HSV) gastrointestinal infections, primarily affecting the esophagus and rectum, are often self-limiting in immunocompetent individuals. Antiviral therapy is suggested for immunocompromised patients, though evidence is limited.

More Related Videos

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

Related Experiment Videos

Last Updated: Jul 3, 2026

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi
12:33

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Virology

Background:

  • Herpes simplex virus (HSV) is a common sexually transmitted infection.
  • Gastrointestinal (GI) HSV infections are less commonly discussed than mucocutaneous manifestations.
  • HSV frequently affects the esophagus and rectum, impacting both immunocompromised and immunocompetent individuals.

Purpose of the Study:

  • To review the clinical presentations of HSV infections within the luminal GI tract.
  • To discuss diagnostic approaches for GI HSV.
  • To outline current treatment options for GI HSV.

Main Methods:

  • Literature review of HSV gastrointestinal infections.
  • Analysis of clinical manifestations, diagnosis, and treatment strategies.
  • Synthesis of information on immunocompromised and immunocompetent patient populations.

Main Results:

  • Esophageal and proctitis are common sites of GI HSV, particularly in specific demographics.
  • In immunocompetent patients, GI HSV is typically self-limiting with minimal need for antiviral therapy.
  • Treatment is recommended for immunocompromised individuals, but robust clinical trial data is lacking.

Conclusions:

  • GI HSV infections present unique challenges in diagnosis and management.
  • Further research, including randomized controlled trials, is needed to optimize treatment for immunocompromised patients.
  • Understanding the spectrum of GI HSV is crucial for effective patient care.