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Related Experiment Video

Updated: Jul 3, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Cocamidopropyl betaine.

Sharon E Jacob¹, Sadegh Amini

¹Department of Dermatology, University of Miami School of Medicine, Miami, FL, USA.

Dermatitis : Contact, Atopic, Occupational, Drug

|July 17, 2008

Summary

Cocamidopropyl betaine (CAPB) is a common cosmetic ingredient causing allergic reactions. Impurities from manufacturing may contribute to this widespread skin sensitization, identified as Allergen of the Year in 2004.

Area of Science:

Dermatology
Cosmetic Science
Toxicology

Background:

Cocamidopropyl betaine (CAPB) is a widely used amphoteric surfactant in personal care products due to its mildness.
Increasing prevalence of delayed T-cell-mediated type IV hypersensitivity reactions to CAPB has been reported.
CAPB was designated Allergen of the Year in 2004 due to rising sensitization rates.

Purpose of the Study:

To investigate the prevalence and potential causes of contact sensitization to Cocamidopropyl betaine (CAPB).

Main Methods:

Literature review on reported hypersensitivity reactions to CAPB.
Analysis of sensitization prevalence data.
Examination of potential roles of manufacturing impurities.

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Main Results:

Contact sensitization prevalence to CAPB ranges from 3.0% to 7.2%.
Impurities like amidoamine and dimethylaminopropylamine are suspected contributors to CAPB sensitization.
Delayed T-cell-mediated type IV hypersensitivity is the primary reaction type.

Conclusions:

The increasing use of CAPB in cosmetics correlates with rising rates of allergic contact dermatitis.
Manufacturing impurities are implicated as key factors in CAPB-induced sensitization.
Further research into impurity profiles and their allergenic potential is warranted.