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Related Experiment Video

Updated: Jul 3, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Confluent and reticulate papillomatosis.

Jashin J Wu¹, Boris H Borazjani, Jeffrey V Benabio

¹Department of Dermatology, University of California, Irvine, Irvine, CA, USA. jashinwu@hotmail.com

Dermatology Online Journal

|July 17, 2008

Summary

Confluent and reticulate papillomatosis is an uncommon skin condition. A six-week course of minocycline effectively cleared the rash in a patient, suggesting its therapeutic potential.

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Area of Science:

Dermatology
Medical Mycology
Pathology

Background:

Confluent and reticulate papillomatosis (CRP) is a rare dermatosis.
Typically presents as asymptomatic, brown, reticulate plaques on the chest.
Etiology remains largely unknown, with fungal infections often ruled out.

Observation:

A 24-year-old male presented with a year-long history of asymptomatic rash.
Clinical examination revealed brown, confluent plaques in a reticulate pattern on the chest and arms.
Dermatopathological examination showed papillomatosis, orthokeratosis, and basal layer melanin pigment.

Findings:

Fungal scraping was negative, excluding superficial fungal infection.
Histopathology confirmed features consistent with CRP.
Treatment with oral minocycline for six weeks resulted in complete resolution of the rash.

Implications:

Minocycline demonstrates significant efficacy in treating confluent and reticulate papillomatosis.
This case highlights minocycline as a viable therapeutic option for this uncommon dermatosis.
Further research into the pathogenesis of CRP may elucidate additional treatment strategies.