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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
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Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

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Local Hyperthermia for Warts Treatment
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Epidermodysplasia verruciformis.

Christopher M Hunzeker1, Anthony C Soldano, Steven Prystowsky

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

This case highlights a rare association between epidermodysplasia verruciformis and multiple non-melanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, in a young woman.

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Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by abnormal susceptibility to human papillomaviruses (HPVs).
  • EV significantly increases the risk of developing non-melanoma skin cancers, particularly squamous cell carcinoma.
  • The association with basal cell carcinoma is less commonly reported.

Observation:

  • A 29-year-old woman presented with an ulcerated nodule and multiple scaly papules/plaques on her face and scalp.
  • She also had pityriasis rosea-like and verruca plana-like lesions on her neck, back, arms, hands, and forearms.
  • Histopathological examination revealed basal cell carcinoma, invasive and in-situ squamous cell carcinoma, and features of epidermodysplasia verruciformis.

Findings:

  • Biopsies confirmed nodular basal cell carcinoma and squamous cell carcinoma (both invasive and in-situ).
  • Histopathology demonstrated characteristic features of epidermodysplasia verruciformis.
  • The patient presented with a complex dermatological condition involving multiple HPV-related lesions and malignancies.

Implications:

  • This case underscores the critical need for vigilant dermatological surveillance in individuals with epidermodysplasia verruciformis.
  • Early detection and management of non-melanoma skin cancers are crucial for improving outcomes in EV patients.
  • Further research into the specific HPV types and genetic mutations associated with EV and varied skin cancers may offer new therapeutic targets.