Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Anaplastic large-cell T-cell lymphoma.

Jennifer A Stein1, Anthony C Soldano, Jo-Ann M Latkowski

  • 1Department of Dermatology, New York University, USA.

Dermatology Online Journal
|July 17, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterizing Longitudinal Melanonychia in Skin of Color.

JAMA dermatology·2026
Same author

Platelet-Rich Plasma Injections and Scalp Cutaneous Malignancies: Clinical Implications and Knowledge Gaps.

International journal of dermatology·2026
Same author

Navigating Melanoma In Situ in the Age of Overdiagnosis.

JAMA dermatology·2025
Same author

Melanoma rates after in vitro fertilization treatment: A TriNetX study.

Journal of the American Academy of Dermatology·2025
Same author

Dermoscopic features of acral melanosis in patients with Fitzpatrick skin types IV-VI.

Clinical and experimental dermatology·2025
Same author

SpotCheck: A skin cancer diagnostic accuracy study comparing teledermoscopy with and without electrical impedance spectroscopy to in-person dermatologist evaluation of patient-identified lesions concerning them for skin cancer.

Journal of the American Academy of Dermatology·2024

This case study discusses a CD30+ cutaneous lymphoma, a type of T-cell lymphoma. Accurate diagnosis requires integrating histopathology with clinical presentation for effective patient management.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous lymphomas represent a heterogeneous group of non-Hodgkin lymphomas.
  • Anaplastic large-cell T-cell lymphoma (ALCL) is a distinct subtype that can manifest cutaneously.
  • CD30 expression is a key immunophenotypic marker in certain lymphomas.

Observation:

  • A 64-year-old woman presented with a two-year history of pruritic, ulcerated nodules and tumors on her trunk and arms.
  • Clinical examination revealed significant skin lesions requiring further investigation.

Findings:

  • Histopathologic examination demonstrated a diffuse infiltrate composed primarily of small lymphocytes.
  • Scattered large atypical multinucleated cells, positive for CD30, were identified.
  • The findings were consistent with a diagnosis of CD30-positive anaplastic large-cell T-cell lymphoma.

Related Experiment Videos

Last Updated: Jul 3, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Implications:

  • This case underscores the necessity of correlating histopathologic findings with clinical presentation for accurate diagnosis of cutaneous lymphomas.
  • Recognizing CD30+ cutaneous lymphoma is crucial for appropriate treatment planning and patient outcomes.
  • Emphasizes the role of immunophenotyping (CD30) in classifying T-cell lymphomas.